Applied and Natural Science Foundation
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Journal of Applied and Natural Science
An International Journal | Print ISSN: 0974-9411 | Online ISSN: 2231-5209
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Abstract
Journal of Applied and Natural Science 8 (1) : 386-391 (2016)
Induction of reactive oxygen species in brain of Etroplus maculatus after exposure to bisphenol A
R. Rejitha?1, K. P. Asifa1 and K. C. Chitra1*
1Department of Zoology, University of Calicut, Malappuram-673635 (Kerala), INDIA
*Corresponding author. E-mail: kcchitra@yahoo.com
Abstract : The present study was aimed to investigate that bisphenol A, an environmental estrogen, exposed at 648 µg/ L concentration for 96 h could induce reactive oxygen species in brain of cichlid fish, Etroplus maculatus. Evaluation of antioxidant enzymes as superoxide dismutase, catalase and glutathione reductase showed a reduction in the activities at 5% level of significance with concomitant increase in the level of hydrogen peroxide generation (from 1.546 ± 0.426 (control), 1.506 ± 0.217 (DMSO) to 1.888 ± 0.368 (24 h), 5.332 ± 0.589 (72 h), 2.392 ± 0.341 (96 h)) and lipid peroxidation (from 2.805 ± 0.33 (control), 2.401 ± 0.309 (DMSO) to 3.596 ±0.373 (24 h), 5.65 ± 0.306 (72 h), 3.834 ± 0.236 (96 h)). The brain marker enzyme, acetylcholinesterase decreased at 24, 72 and 96 h in time-dependent manner than that of control groups. The present findings summarize that the increased production of oxygen free radicals due to the exposure of an environmental estrogen, bisphenol A at sub lethal concentration (648 µg/ L) for 96 h inhibited the activities of antioxidant enzymes thereby induced oxidative stress in brain of fish. The decreased activity of brain marker enzyme, acetylcholinesterase reflect the neurotoxicity of bisphenol A in brain of fish, Etroplus maculatus and this could be one of the possible mechanisms of bisphenol A-induced neurodevelopmental disorders in fish.

Keywords : Acetyl cholinesterase, Bisphenol A, Brain, Etroplus maculatus, Oxidative stress, ROS
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