Journal of Applied and Natural Science 6 (2): 638-643 (2014)
Studies on the effect of ethanolic extract of propolis in BALB/c mice.
Preeti Kalia1*, Neelima R. Kumar1 and Kusum Harjai2
1Department of Zoology, Panjab University, Chandigarh, INDIA
2Department of Microbiology, Panjab University, Chandigarh, INDIA
*Corresponding author. E-mail: email@example.com
Abstract : Propolis is widely used since ages for the treatment of various ailments. Present study focussed on the
toxicity profile of ethanolic extract of propolis on BALB/c mice. The effect of different concentrations of propolis (300,
500, 1000 mg/kg body weight) was analysed by studying the biochemical, haematological and histological changes
in mice for 28 days. No significant difference in various parameters were observed in groups of mice treated with
propolis and the normal control (p>0.05). Histological findings on liver, spleen, kidney and brain revealed normal
architecture. The ethanolic extract of propolis did not produce significant toxic effect in mice and hence can be
utilized for nutraceuticals formulations.
Keywords : Biochemical, Histological, Propolis, Toxicology.