Applied and Natural Science Foundation
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Journal of Applied and Natural Science
An International Journal | Print ISSN: 0974-9411 | Online ISSN: 2231-5209
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Journal of Applied and Natural Science 4(1):87-91(2012)
Citric acid: A potential permeabilizer against multiple drug resistance enteropathogenic Escherichia coli
Preeti G. Dharmik1*, Ashok V. Gomashe1 and Bharat J. Wadher2
1Department of Microbiology, Shri Shivaji Science College, Congress Nagar, Nagpur-440 012 (Maharashtra), INDIA 2P.G. Department of Microbiology, Rashtrasant Tukdoji Maharaj Nagpur University, L.I.T Campus Premises, Nagpur- 440 033 (Maharashtra), INDIA *Corresponding author. E-mail:
Abstract : Enteric diseases enter through the mouth and are usually spread by contaminated food, water or contact with contaminated vomit or feces. Enteric infection encompasses all the infections of the intestinal tract. These intestinal infections include organisms like Escherichia coli, Salmonella, Shigella, Klebsiella, Proteus etc. Out of these, E. coli are one of the common causes of enteric infection. In spite the introduction of a wide variety of antimicrobial agents against enteric diseases, life threatening infections caused by E. coli contributes to morbidity and mortality in patients. The present study was conducted to determine the antibiotic sensitivity pattern of E. coli obtained from stool samples and potentiation of antibiotic activity by citric acid against multiple drug resistant E. coli. Out of the 200 isolates of E. coli, 150 were found to be resistant to one or more antibiotics tested. 0.05% and 0.1% citric acid was found to be effective in increasing the potency of the all the antibiotics used in the study.

Keywords : Antimicrobial, Enteric, Escherichia, Potentiation, Potency, Resistance
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