Journal of Applied and Natural Science 4(1):1-4(2012)
Adrenal hormone insufficiency impact on antioxidant metabolism in the tissues of rat
K. Kavitha, M. Mohana Radhika, E. Madhuri, W. Rajendra and M. Bhaskar
1Department of Zoology, S.V. University, Tirupati-517502 (A.P.), INDIA 2Department of Zoology, Yogivemana University, Kadapa (A.P.), INDIA *Corresponding author. E-mail: email@example.com
Abstract : The effect of adrenelectomy was studied on the antioxidant metabolism in different tissues (Liver, heart, kidney and muscle) of rat. G-6-PDH was increased significantly in liver and heart and the same was decreased in kidney with a non significant change in muscle. SOD was significantly increased in heart and muscle. Catalase was significantly decreased in liver and muscle and was increased significantly in kidney. XOD showed significant decrease in liver and increase in heart, kidney and muscle. The present finding, in general, exhibit tissue specific alterations in free radical metabolism in conjunction with antioxidant defence mechanisms during adrenal hormone deficiency. It is also clear from the results that the mechanisms involved in selective activation / inhibition of different pathways seems to reflect multifaceted physiological adaptations as a compensatory measure during induced adrenalectomy.
Keywords : Adrenalectomy, Antioxidant metabolism, Sham operated, Tissue