Journal of Applied and Natural Science 3(2):206-210(2011)
Effect of different fractions of Hibiscus rosa sinensis leaf extract on islets of Langerhans and antioxidant activity in non-obese diabetic (NOD) mouse
Fahmi S. Moqbel and Prakash R. Naik *
Endocrinology Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-570 006 (Karnataka), INDIA *Correspondence author. E-mail: email@example.com
Abstract : The present investigation was undertaken to study the effect of Hibiscus rosa sinensis leaf extract fractions on islets of Langerhans, total antioxidant activity in non-obese diabetic (NOD) mouse. Two sets of experiments were conducted. First experiment was designed to test the hypoglycemic properties of different isolated fractions. Five fractions were screened for hypoglycemic property. Fractions F 3 , F 4 and F 5 showed hypoglycemic in NOD mice. Second set of experiment was conducted to assess the effects of above fractions on the diameter of islets of Langerhans and on the β -cells number and total antioxidant capa City (TAC). All the fractions had a significant effect in the enhancement of diameter of islets of Langerhans and the β -cell number and antioxidant active (total antioxidant capa City) compared with control NOD mice.
Keywords : Blood glucose, Islets of langerhans, Total antioxidant capa City, Non-obese diabetic mice